Mar 15, The incidence of Rh incompatibility in the Rh-negative mother who is also ABO incompatible is reduced dramatically to % and is believed to. PDF | On Dec 1, , Manuel Olivares G and others published Anemia Tardía en Niños con Incompatibilidad Rh y ABO. Download Citation on ResearchGate | Enfermedad hemolítica del recién nacido por incompatibilidad ABO | The hemolytic disease of the newborn due to ABO.

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The first group includes the states of Coahuila, Queretaro, and Veracruz which have moderate frequencies of the and alleles first quadrant. It prevents the mother’s body from making any Rh antibodies that could cause serious health problems in the newborn or affect a future pregnancy. People who don’t carry the protein are Rh-negative. In Mexico, the rate of blood donations in increased from Interestingly, those immunogenic variants are widely distributed among indigenous and mestizo people [ 4755 ].

The blood type O Rh D was more frequent in Puebla For the above, it is necessary to implement effective programs among health institutions to get specific blood types and products according to their geographic distribution.

View at Google Scholar V. Additionally, other works have related genetic ancestry in Mexico to susceptibility to breast cancer [ 51 ] and diabetes [ 52 ]. The first studies were performed by Lisker and colleagues, in indigenous and mestizo populations by studying several blood antigens [ 922 ]; however, few populations were studied and currently there is lack of information about blood groups distribution in the country, whereby it is essential to get this information to help health institutions for the effective management of their blood banks that facilitate transplant medicine practices.

Not everyone carries this protein, though most do. La inmunoglobulina contra el Rh impide que el cuerpo produzca anticuerpos, por lo que evita que ocurra anemia fetal grave en un embarazo futuro. This test checks her blood type and Rh factor. According to these observations, populations were analyzed to know if they were in the Hardy-Weinberg equilibrium HWE. The fourth group has higher frequencies of and alleles and includes the states of Sinaloa, Sonora, Baja California, Michoacan, Jalisco, and Nayarit which belong to northwest and west of Mexico Table 3.


Data were analyzed with the Minitab V17 software Minitab Inc. An Rh factor is a protein found on some red blood cells RBCs. The frequencies observed in Coahuila, Nuevo Leon, Jalisco, and Ciudad de Mexico were similar to that previously reported [ 30 — 34 ]; however, for Durango, Puebla, and Guanajuato, proportions of blood antigens were different compared with our results [ 29313435 ].

It is important to take into account the fact that Mexicans are a mestizo population recently established, composed of the admixture of European, African, and majorly Amerindians [ 1920 ] where the allele is nearly fixed [ 373946 ].

Rh incompatibility usually isn’t a problem if it’s the mother’s first pregnancy. Similar to ours, these works reported that populations in the north have higher heterozygosities with respect to those located in the center and the south of the country [ 20 ].

Her Rh factor may play a role in her baby’s health, so it’s important to know this information early in pregnancy. Additionally, these works have explored the possible effects of the genetic content in the clinic context [ 19 ].

BioMed Research International

Cruz-Zamudio3 Tania G. Moreover, this piece of information contributes to the knowledge of the genetic structure of the Mexican populations which could have significant implications in different fields of biomedicine. Clustering of populations was tested with bootstrap replicates; the numbers at the nodes are the bootstrap values.

If this happens, the mother’s body recognizes the Rh protein as a foreign substance. Jncompatibilidad, we found that the Rh D locus was in HWE; however, more studies are needed to corroborate our observations.


The allele frequencies of the ABO and D loci were estimated from the phenotypes observed.


The authors thank the staff of Salud Digna clinics for their support during this work. A total ofindividuals from 17 states of Mexico were studied between the years and For specific medical advice, diagnoses, and treatment, consult your doctor. This research was supported by an internal budget of Salud Digna para Todos.

In the second; Sinaloa, Sonora, Jalisco, Michoacan, Nayarit, Baja California, and Durango were included which have higher frequencies of the and alleles in the case of Durango. The overall gene diversity was higher at the ABO locus than the D locus ; similarly, the gene diversity within populations was higher in the ABO locus than the D locus.

Durante el embarazo, pueden surgir problemas si su factor Rh es negativo y el feto es Rh positivo. National average of blood group: The frequency observed was slightly similar to those found in indigenous populations [ 37 — 39 ], reflecting the complex processes of the admixture giving rise to Mexican mestizo populations [ 9 ]. From each people, clinical history was obtained before screening for their demographic data.

A geographic clustering in these groups was not evident Figure 3. En algunos casos, el feto puede morir debido a un estado de anemia. El feto puede heredar el factor Rh del padre o de la madre.

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